Info
🌱 來自: sjögren’s syndrome
Clinical manifestations of sjögren’s syndrome
- Dry eyes (keratoconjunctivitis sicca): ↓ tear production; burning, scratchy sensation
- Dry mouth (xerostomia): difficulty speaking/swallowing, dental caries, xerotrachea, thrush
- Parotid gland enlargement: intermittent, painless, typically bilateral
- Vaginal dryness and dyspareunia
- Recurrent nonallergic rhinitis/sinusitis due to upper airway gland involvement
- Extraglandular manifestations: arthritis, interstitial nephritis (40%), type I RTA (20%), cutaneous vasculitis (25%), PNS >CNS neurological disease (20%), ILD, PBC
- ↑ risk of lymphoproliferative disorders (~50× ↑ risk of lymphoma and WM in 1° Sjögren’s)
- Neonatal lupus, including fetal skin rash or heart block (a/w SSA and/or SSB antibodies)