Irritable bowel syndrome
(JAMA 2015;313:949; Gastro 2015;149:1399 & 2018;154:1140)
參考➡️ Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial 參考➡️ Irritable bowel syndrome: a clinical review
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Abd discomfort for 6+ mos a/w ≥2: improves w/ defecation, Δ stool frequency, Δ stool form
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IBS-C (constipation predominant) vs. IBS-D (diarrhea predominant) vs. IBS-M (mixed) vs. IBS-U (unclassified). Sx may be affected by stress, diet, lifestyle, probably microbiome.
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Treatment: cog. behavior Rx, probiotics, anti-spasmodics, exercise, neuromodulators (eg, TCA, SSRI), Δ diet (↓ fermentable carbs w/ low FODMAP diet, lactose-free diet)
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IBS-C: ↑ fiber, laxatives (lubiprostone, linaclotide, tegaserod, tenapanor), biofeedback
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IBS-D: loperamide, rifaximin, eluxadoline, bile acid sequestrants, alosetron
Explain by ChatGPT
Irritable bowel syndrome (IBS) is a chronic disorder that affects the large intestine. Symptoms include abdominal pain, bloating, and changes in bowel habits.
IBS is divided into four subtypes: IBS-C (constipation predominant), IBS-D (diarrhea predominant), IBS-M (mixed), and IBS-U (unclassified). Symptoms may be affected by stress, diet, lifestyle, and the microbiome.
Treatment of IBS includes cognitive behavioral therapy, probiotics, anti-spasmodics, exercise, and neuromodulators such as tricyclic antidepressants and selective serotonin reuptake inhibitors. Dietary changes include a low FODMAP diet and a lactose-free diet.
IBS-C is treated with fiber, laxatives, and biofeedback. IBS-D is treated with loperamide, rifaximin, eluxadoline, bile acid sequestrants, and alosetron. IBS-M is treated with loperamide and rifaximin.
窩的英文不太好
腸易激綜合徵 (IBS) 是一種影響大腸的慢性疾病。症狀包括腹痛、腹脹和排便習慣改變。
IBS 分為四種亞型：IBS-C（便秘為主）、IBS-D（腹瀉為主）、IBS-M（混合）和 IBS-U（未分類）。症狀可能會受到壓力、飲食、生活方式和微生物組的影響。
IBS 的治療包括認知行為療法、益生菌、抗痙攣藥、運動和神經調節劑，例如三環類抗抑鬱藥和選擇性血清素再攝取抑製劑。飲食變化包括低 FODMAP 飲食和無乳糖飲食。
IBS-C 用纖維、瀉藥和生物反饋治療。 IBS-D 用洛哌丁胺、利福昔明、eluxadoline、膽汁酸多價螯合劑和阿洛司瓊治療。 IBS-M 用洛哌丁胺和利福昔明治療。