Workup-nephrotic syndrome
(BMJ 2008;336:1185)
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U/A + sediment: usually benign; ± oval fat bodies (“Maltese crosses”; NEJM 2007;357:806)
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Measure proteinuria: 24-h urine or spot urine protein/Cr ratio (not accurate in AKI), renal bx
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2° causes: ↑ HbA1C + retinop. → DM; ✓ ANA, anti-dsDNA, tox screen, C3/C4, SPEP/light chains, fat pad bx, cryocrit, HBV/HCV, HIV, RPR, APLA2R Ab, age-approp. CA screen