Pure red cell aplasia

PRCA

DOI: 10.1182/blood.2021010898

• Destructive antibodies or lymphocytes → ineffective erythropoiesis

破壞性抗體或淋巴細胞 → 無效性造血

• Associated with thymoma, CLL, parvovirus infection, autoimmunity, drugs

• Diagnostic studies: lack of erythroid precursors on BM bx, other lines normal

• Treatment-Pure red cell aplasia

• Rare bone marrow disorder

• malproductive, reticulocytopenic, normocytic anemia and disappearance of erythroid precursors

• Nosologically resides within single-lineage cytopenias

• Shares clinical features with BM failure syndromes and autoimmune cytopenias