Info

🌱 來自: chronic myelogenous leukemia (CML)

disease classification and manifestations of chronic myelogenous leukemia (CML) 

(WHO; NCCN v 2.2022)

Chronic phase (CP) 🌻

• <15% blasts (peripheral or bone marrow).
• Risk stratification based on
  • Sokal score (Blood 1984;63:789) 
  • Euro scores (J Clin Pathol 2001;54:491)
• (3–5y pre-TKI)
• 85% of pts, asx, no criteria for accelerated or blast crisis

Accelerated phase (AP) 🩰

• 15% blasts, or 10-19% blasts in PB or bone marrow

• ≥20% basos, of total in blood or bone marrow
• (12–18 mos pre-TKI)
• plts <100k,
• clonal evolution (karyotype changes) not seen at dx
• progressive splenomegaly

Blastic phase (BP) 🤯

• ≥20% blasts (peripheral or marrow)
• and/or extramedullary leukemia

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• Most asx or may have mild constitutional s/s related to splenomegaly.

disease progression

• worsening constitutional sx
• bone pain
• ↑ spleen size