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🌱 來自: Pharmacogenomics

Drug transporters

P-gp (MDR-1)

• P-gp & its encoding gene MDR-1 (ABCB1) expressed in high levels in brain vessels, adrenal glands, kidney, liver, & GI tract
• P-gp is involved in the transport of hydrophobic drugs including doxorubicin, paclitaxel, irinotecan, hormones, & carcinogens
• Multidrug resistance proteins act as drug efflux pumps rendering cells resistant to cytostatic drugs
• Three most common SNPs are P-gp*6 (22-56% in Caucasians), P-gp*7, & P-gp*8