Info

🌱 來自: gastrointestinal stromal tumor

Treatment of unresectable and metastatic GIST

• Prior to TKI, GIST considered not sensitive to chemo
• Imatinib Mesylate
  • Resistance to imatinib/POD:
    • 1° = POD <6 mos (more common in exon 9 mt),
    • 2° = >6 mos (typically develop separate 2° resistance Mts in KIT)
• Sunitinib suNITinib
• Regorafenib regoRAFenib
• Ripretinib riPREtinib
• Avapritinib avaPRItinib