protease inhibitors - PI-Antiretrovirals (ARVs)

atazanavir (ATV; Reyataz) darunavir (DRV; Prezista) lopinavir (LPV; Kaletra) PIs given w/boosters ritonavir or cobicistat for ↑ PK Class: GI intol; hepatotoxicity; inhibit CYP450 (many DDIs, eg statins, steroids, DOACs); ↑ glc; hyperlipid (less w/ ATV); MI (NEJM 2007;356:1723) ATV: crystalluria → nephrolithiasis DRV: rash (10%); possible sulfa cross-reactivity