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🌱 來自: treatment of chronic myelogenous leukemia (CML)

Milestones of Therapy of treatment of chronic myelogenous leukemia (CML)

Chronic Myeloid Leukemia (CML) Treatment Milestones

BCR-ABL1 ratio <10% IS = 1-log reduction by QT- PCR

• early molecular response
• 3 mo

BCR-ABL1 ratio <1% IS = 2-log reduction by QT-PCR (CCyR)

• complete cytogenetic response
• 6 mo

BCR-ABL1 ratio <0.1% IS = 3-log reduction by QT-PCR (MMR)

• major molecular response
• 12 mo

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BCR-ABL1 ratio

BCR-ABL1 mRNA: ABL mRNA in peripheral blood. International Scale (IS) standardizes across labs by normalizing to BCR-ABL1:ABL1 ratio in a cohort of unRx’d patients.