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🌱 來自: approach to rheumatic disease

ddx & approach to common inpatient rheum presentations

• FUO
  • GCA/PMR, AOSD, SLE, inflamm arthr, Taka- yasu, PAN, ANCA ⊕ vasc, cryo, HSP, VEXAS
  • ESR, CRP, RF, ANCA, ± cryo
• Pulm HTN
  • Scleroderma (limited >diffuse), MCTD, SLE, PM/DM (less common)
  • Scl-70, centromere, RNA Pol III, RNP
• DAH
  • ANCA ⊕ vasc, Goodpasture’s, SLE, APS
  • ANCA, GBM, C3/C4, APLA
• ILD
  • Scleroderma (diffuse >limited), sarcoid, RA, DM, PM, antisynthetase syndrome, Sjögren’s, MCTD, SLE (esp. pleura), ANCA ⊕ vasc (esp. MPA)
  • Scl-70, RF/CCP, CK, aldolase, ± myositis specific Abs, Jo-1, Ro/La, ANCA
• Pleuro- pericarditis
  • SLE, scleroderma, RA, MCTD, DM/PM, ANCA ⊕ vasc, Sjögren’s, AOSD, PAN
  • dsDNA, RF/CCP, Sm, Ro/La, Scl-70, RNP, ANCA
• AKI + active sed. or CTD s/s
  • SLE (GN or nephrotic), ANCA ⊕ vasc (GN), scleroderma renal crisis, Sjögren’s (RTA/TIN), PAN (infarct), HSP, Goodpasture’s, cryo, APS
  • dsDNA, Sm, Ro/La, RNP, C3/C4, Scl-70, RNA Pol III, ANCA, GBM, cryos, APLA
• Neuropathy
  • ANCA ⊕ vasc, SLE, Sjögren’s, cryo, sarcoid, RA, PAN
  • Ro/La, ANCA, cryo RF/CCP, HCV, HBV