Disseminated intravascular coagulation (DIC)
(NEJM 2014;370:847)
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Etiologies: trauma, shock, infection, malignancy (esp. APL), obstetric complications
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pathogenesis of disseminated intravascular coagulation (DIC):
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Diagnosis : ↑ PT, ↑ PTT, ↓ fibrinogen (may be nl b/c acute phase), ⊕ FDP/D-dimer, ↓ plts, ⊕ schistos, ↑ LDH, ↓ hapto; chronic DIC: ⊕ FDP/D-dimer, variable plts, other labs nl
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Treatment: Rx underlying process; support w/ FFP, cryo (goal fbgn >100 mg/dL) & plts