Info

🌱 來自: hyperkalemia

drug induced hyperkalemia

• A wide range of drugs can cause hyperkalemia by a variety of mechanisms.
• Drugs can interfere with potassium homoeostasis either by promoting transcellular potassium shift or by impairing renal potassium excretion.
• Drugs may also increase potassium supply.
• The reduction in renal potassium excretion due to inhibition of the renin-angiotensin-aldosterone system represents the most important mechanism by which drugs are known to cause hyperkalemia.
• Medications that alter transmembrane potassium movement
  • include amino acids,
  • beta-blockers,
  • calcium channel blockers,
  • suxamethonium, and
  • mannitol.
• Drugs that impair renal potassium excretion are mainly represented by
  • angiotensin-converting enzyme inhibitors,
  • angiotensin-II receptor blockers,
  • direct renin inhibitors,
  • nonsteroidal anti-inflammatory drugs,
  • calcineurin inhibitors,
  • heparin and derivatives,
  • aldosterone antagonists,
  • potassium-sparing diuretics,
  • trimethoprim, and
  • pentamidine.
• Potassium-containing agents represent another group of medications causing hyperkalemia.