Info

pretransplant_evaluation

  • Hx: KPS, prior therapy, drug allergies, prior infxn, & social support
  • Physical exam: Comprehensive—oral cavity/skin for nidus for infxn, CNS exam, assessment of LAN
  • Labs: CBC, chemistries w/ liver & renal fxn, 24-h urine for accurate Cr clearance
  • Imaging: CXR or CT chest
  • Cardiac fxn: EKG & ECHO (or MUGA)
  • PFT including DLCO
  • Dz-specific restaging studies:
    • BMA/bx, CT or PET/CT in pts w/ certain lymphomas, & SPEP/UPEP w/ IFE, serum FLCs & skeletal assessment in pts w/ MM
  • Transplant-related mortality for SCT can be estimated using the HCT-CI (BBMT 2015;21:1479)
  • comprehensive geriatric assessment in older pts

Pretransplant evaluation for allo

  • Hx: PS, comorbidities, prior Rx, drug allergies, prior infxn, social support system, FHx/sibling info
  • PE: Assess oral cavity/skin for nidus for infxn, CNS exam, assessment of LAN & HSM
  • Labs: CBC, chemistries w/ liver & renal fxn, ABO, viral serologies (esp CMV)
  • Other diagnostics: CXR or CT chest, ECG & study of cardiac fxn (echo or MUGA), PFTs including DLCO; dz-specific restaging studies (BMA/Bx, imaging as indicated)