NOTE

🌱 created from: management_nonmetastatic_disease_of_anal_cancer

nigro_protocol

• Mitomycin

  • 10 mg/m2 IV (maximum 20 mg per dose)
  • Infuse as slow IV push or slow infusion in NS¶ (over 15 to 30 minutes).[3]
  • Days 1 and 29

• Fluorouracil (FU)

  • 1000 mg/m2 per day IV (maximum daily dose 2000 mg)
  • Dilute in 500 to 1000 mL D5W¶ and administer as continuous infusion over 24 hours per day for four days (96 hours).
  • Days 1 through 4, and days 29 through 32

• Radiotherapy (45 to 50.4 Gy)

  • 1.8 Gy daily,
  • five days per week Begin within 24 hours of the administration of chemotherapy. Start on day 1 (total of five weeks)

• Pretreatment considerations_of_nigro_protocol

• Role of mitomycin

• mitomycin