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Tetracyclines of Important Antibacterial Drug Interactions

  • Antacids or drugs containing calcium, magnesium, iron, or aluminum
  • Can result in decreased oral absorption of tetracyclines. Administer tetracycline 2 h before or 6 h after interacting drug.
  • Warfarin
  • Increased effect of warfarin. Monitor levels closely if drugs are given concomitantly.
  • Eravacycline: Strong CYP3A4 inducers (e.g., rifampin)
  • Reduced eravacycline efficacy