Second-line or maintainence therapy for idiopathic thrombocytopenic purpura
- Romiplostim, el/avatrombopag
- TPO-R agonists → ↑ plt prod
- Rituximab (anti-CD20) ± dex
- anti–B-cell Ab
- Splenectomy* (less common)
- ~65% long-term remission
- AZA,
- CYC,
- MMF
- Immunosuppressants
- Danazol: 600 mg/d
- Androgen (hirsutism) ↓ plt clearance
- Fostamatinib
Treatment algorithm for steroid dependent/unresponsive patients
