surgery and radiation for local control of breast cancer

Intervention	Indication
Breast conserving	Stage I–II, lumpectomy + sentinel lymph node biopsy* + RT
Modified radical mastectomy	Large tumor relative to breast, multicentric dis., prior chest RT, diffuse microcalcifications, ⊕ margins after lumpectomy
Post mastectomy Radiation	≥4 ⊕ LN, tumor >5 cm, ⊕ surgical margins, chest wall or skin involvement (Lancet 2014;384:1848)