Secondary Hyperaldosteronism
(extra-adrenal disorders, ↑ aldosterone is renin-dependent) 2° hyperaldosteronism (eg, renovascular dis., renin-secreting tumor)
Primary reninism: renin-secreting tumor (very rare) Secondary reninism: renovascular disease: RAS, malignant hypertension; edematous states w/ ↓ effective arterial volume: CHF, cirrhosis, nephrotic syndrome; hypovolemia, diuretics, T2D, Bartter’s (defective Na/K/2Cl transporter ≈ receiving loop diuretic), Gitelman’s (defective renal Na/Cl transporter ≈ receiving thiazide diuretic)