Immune Complex (IC) Disease (granular staining)
Renal-Limited Diseases
- Infection-Related GN
- (Staph & Strep; ↓ C3, ± ASLO)
- Membranoproliferative GN (MPGN) (↓ C3)
- Fibrillary and immunotactoid GN (normal C3/C4)
- IgA nephropathy (normal C3, ±↑ IgA)
- (NEJM 2013;368:2402; CJASN 2017;12:677)
Systemic Diseases
- SLE (CJASN 2017;12:825)
- (⊕ ANA, ⊕ anti-dsDNA, ⊕ anti-Sm, ↓ C3, ↓ C4)
- Cryoglobulinemia
- (⊕ cryocrit, ⊕ RF, ⊕ HCV, SPEP, ↓ C3, ↓ C4)
- Endocarditis
- (fever, ⊕ BCx, valvular disease, ↓ C3)
- Henoch-Schönlein purpura