Info

🌱 來自: acid-base disturbances

physiology of acid-base disturbances

Proximal tubule

Reabsorbs majority of filtered bicarbonate (normally about 80%) Produces and secretes ammonium

Thick ascending limb of Henle’s loop

Reabsorbs most of remaining filtered bicarbonate (normally about 10%–15%)

Distal nephron

• Reabsorbs virtually all remaining filtered bicarbonate as well as any secreted bicarbonate (Type A intercalated cells)
• Acidifies tubular fluid (Type A intercalated cells)
• Secretes bicarbonate (Type B intercalated cells)
• Secretes ammonia and ammonium (type A and non-A, non-B intercalated cells)