Info
Pancreatic head (uncinate process) ductal (M/D) adenocarcinoma s/p laparoscopic Whipple operation on ___/___/___, pT3N1(___/___)M0, stage IIB, margin involved by invasive carcinoma, LVI___, perineural invasion ___, vascular invasion ___
- Initial presentation:
___ - Treatment plan: adjuvant chemotherapy
___ - Follow up parameter:
- CA-199, abdominal CT scan
___
- CA-199, abdominal CT scan
- adjuvant_treatment_info:
- purpose: “The purpose of adjuvant treatment is to improve DFS and OS but not for cure.”
- eligibility: “Adjuvant treatment should be administered to patients who have not had neoadjuvant chemotherapy and who have adequately recovered from surgery; treatment would be initiated within 12 weeks.”
- restaging: “If systemic chemotherapy precedes CCRT, restaging with imaging should be done after each treatment modality.”
- candidates: “Patients who have received neoadjuvant CCRT or chemotherapy may be candidates for additional chemotherapy following surgery and multidisciplinary review.”
- options_dependency: “The adjuvant therapy options are dependent on the response to neoadjuvant therapy and other clinical considerations.”
adjuvant_chemotherapy_explanation at date: ___/___/___
- Gem_alone:
- study: “CONKO-001 study”
- dosage: “1000mg/m2 D1,8,15, q4w for 6 months”
- OS_HR: “0.76”
- FU_LV:
- dosage: “425/20 IV bolus D1-D5 QM for 6 months”
- mOS: “23.6 month”
- GEM_capcitabine:
- dosage: “1660mg/m2 D1-D21, Q4weeks”
- HR: “0.82”
induction_chemotherapy_sequence
- description: “Explain induction chemotherapy followed by CCRT followed by subsequent chemotherapy: GEM/5FU ⇒ CCRT with 5FU or GEM ⇒ GEM/5FU.”
- CCRT_with_weekly_FU_LV:
- description: “Explain CCRT with weekly 5FU/LV.”