Renal losses of Hypovolemic-hypotonic-hyponatremia

• (UNa >20 mEq/L, FENa >1%):
• diuretics (esp. thiazides, because loop diuretics ↓ tonicity of medullary interstitium, Δ for H2O absorption, & ∴ urine concentrating ability), salt-wasting nephropathy, cerebral salt wasting, mineralocorticoid deficiency