GI prophylaxis if taking ASA and nonsteroidal anti-inflam drug

(Am J Gastro 2009;104:728)

• PPI if h/o PUD/UGIB and either (a) on P2Y12 inhib or anticoag, or (b) ≥2 of the following: >60 y, steroids or dyspepsia. Low bleeding risk Pts unlikely to benefit (Gastro 2019;157:403).
• Consider Δ non-selective NSAID to selective COX-2 inhibitor (↓ PUD & UGIB but ↑ CV events), if low CV risk & not on ASA