Info

🌱 來自: Irinotecan

Adverse Reactions of Irinotecan

TLDR: Cholinergic syndrome: 拉肚子、冒汗、血球低下、掉頭髮、T.bili、上升

• >10%:

• Cardiovascular: Vasodilation (9% to 11%)

• Central nervous system: Cholinergic syndrome (47%; includes diaphoresis, flushing, increased peristalsis, lacrimation, miosis, rhinitis, sialorrhea), pain (23% to 24%), dizziness (15% to 21%), insomnia (19%), headache (17%), chills (14%)

• Dermatologic: Alopecia (46% to 72%), diaphoresis (16%), skin rash (13% to 14%)

• Endocrine & metabolic: Weight loss (30%), dehydration (15%)

• Gastrointestinal: Diarrhea (late: 83% to 88%, grades 3/4: 14% to 31%; early: 43% to 51%, grades 3/4: 7% to 22%), nausea (70% to 86%), abdominal pain (57% to 68%), vomiting (62% to 67%), abdominal cramps (57%), anorexia (44% to 55%), constipation (30% to 32%), mucositis (30%), flatulence (12%), stomatitis (12%)

• Hematologic & oncologic: Anemia (60% to 97%; grades 3/4: 5% to 7%), leukopenia (63% to 96%, grades 3/4: 14% to 28%), thrombocytopenia (96%, grades 3/4: 1% to 4%), neutropenia (30% to 96%; grades 3/4: 14% to 31%)

• Hepatic:

  • Increased serum bilirubin (84%), increased serum alkaline phosphatase (13%)

• Infection: Infection (14%)

• Neuromuscular & skeletal: Weakness (69% to 76%), back pain (14%)

• Respiratory: Dyspnea (22%), cough (17% to 20%), rhinitis (16%)

• Miscellaneous: Fever (44% to 45%) Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1)