Growth hormone deficiency
↓ GH
- ↑ chronic risk for osteoporosis, fatigue, decreased lean body mass
- Dx with failure to ↑ GH w/ appropriate stimulus (eg, insulin tolerance test, glucagon stimulation, and macimorelin stimulation)
- GH replacement in adults controversial (Annals 2003;35:419; NEJM 2019;380:2551)