Noninvasive positive-pressure ventilation of COPDAE

👉 COPD Exacerbation Treatment

• Initiate early if

  • moderate/severe dyspnea,
  • ↓ pH / ↑ PaCO2,
  • RR >25

• Results in 58% ↓ intubation, ↓ LOS by 3.2 d, 59% ↓ mortality

• Contraindications:

  • Δ MS,
  • inability to cooperate or clear secretions,
  • hemodynamic instability,
  • UGIB

• (NEJM 1995;333:817; Annals 2003;138:861; Cochrane 2004;CD004104; ERJ 2005;25:348)