Autoimmune Polyglandular Syndromes

(NEJM 2018;378:1132) Type Features

I

• (APECED)
  • Child onset,
  • mucocutaneous candidiasis,
  • hypoparathyroidism,
  • adrenal insufficiency,
  • AIRE mutation

II

• Adult onset,
• adrenal insufficiency,
• autoimmune thyroid disease,
• diabetes mellitus type 1; polygenic