Treatment-Vitamin B12 deficiency

• 1 mg B12 IM qd × 7 d → q wk × 4–8 wk → q month for life

• neurologic abnormalities are reversible if treated w/in 6 mos

• folate can reverse hematologic abnormalities of B12 deficiency but not neurologic changes (and can “steal” B12 stores → worsening of neuro complications)

• oral supplementation (2 mg qd) appears feasible as well (Cochrane Rev CD004655) even w/o IF