Info
hd-mtx_protocol
| Description | Timing | |
|---|---|---|
| Pre-hydration | 5% Dextrose 3000 ml + KCl (2 mEq/ml) 15 ml + NaHCO3 (0.83 mEq/ml) 180 ml IVF | Continuously (Pre-Methotrexate) |
| Pre-medication | Granisetron 1 mg IV PUSH | 30 mins before Methotrexate |
| Chemotherapy | Methotrexate 3000 mg/m2 (D2) | 4900 mg in 5% Dextrose 1000 ml IVF over 4 hrs, rate 299 ml/hr at 08:00 (D2) |
| Vincristine 1.4 mg/m2 (D1) | 2 mg IV PUSH at 17:45 (D1) | |
| Mercaptopurine (專案進口) /D1-D7 | 100 mg PO daily at 13:00 (D1) 09:00 (D2-7) | |
| Post-hydration | 5% Dextrose 2000 ml + KCl (2 mEq/ml) 10 ml + NaHCO3 (0.83 mEq/ml) 120 ml IVF | 125 ml/hr at 12:00 (D2) |
| 5% Dextrose 3000 ml + KCl (2 mEq/ml) 15 ml + NaHCO3 (0.83 mEq/ml) 180 ml IVF | 125 ml/hr at 04:00 (D3) x 2 days | |
| Others | Leucovorin 30 mg PO Q6H x 5 days | 06:00 (D3) |
- Check urine pH at 21:00 (D1), 06:00 (D2) then BID (06:00, 18:00)
- Check MTX level at the 4 hrs, 24 hrs, and 48 hrs after the start of MTX infusion
- Check CBC/DC, BCS at 8AM on D4
- Record U/O and BW QD