Etiologies-pancytopenia

• Hypocellular bone marrow (nl cellularity ~100 – age): aplastic anemia, hypoplastic MDS

• Cellular bone marrow: MDS, aleukemic leukemia, PNH, severe megaloblastic anemia

• Myelophthesis (marrow replacement, PMF); systemic dis. (hypersplen, sepsis, EtOH/toxin)

Explain by ChatGPT

1. Aplastic anemia, hypoplastic myelodysplastic syndrome, aleukemic leukemia, paroxysmal nocturnal hemoglobinuria, and severe megaloblastic anemia can all cause pancytopenia.
2. Pancytopenia can also be caused by myelophthisis, which is replacement of the bone marrow by another tissue.
3. Systemic diseases such as hypersplenism, sepsis, and alcohol or toxin exposure can also lead to pancytopenia.

窩的英文不太好

1. 再生障礙性貧血、骨髓增生異常綜合徵、白血病、陣發性睡眠性血紅蛋白尿、重症巨幼紅細胞性貧血均可引起全血細胞減少。
2. 全血細胞減少症也可能由骨髓瘤引起，這是一種用另一種組織替代骨髓的疾病。
3. 全身性疾病如脾功能亢進、敗血症、酒精或毒物接觸等也可導致全血細胞減少。