Info

🌱 來自: waldenstrom’s macroglobulinemia (WM)

clinical manifestations of waldenstrom’s macroglobulinemia (WM)

• Fatigue : anemia

Tumor infiltration: 骨肝脾淋

• BM (cytopenias)
• hepatomegaly
• splenomegaly
• lymphadenopathy

Circulating monoclonal IgM

HyperVISCOSITY syndrome (~15%):

神經 : 心 : IgM : autoimmune hemolytic anemia

• Neurologic:

  • blurred vision (“sausage” retinal veins),
  • HA,
  • dizziness,
  • Δ MS.

• Cardiopulmonary:

  • congestive heart failure, pulm. infiltrates.
  • Type I cryoglobulinemia → Raynaud’s phenomenon
  • Platelet dysfxn → mucosal bleeding

• IgM deposition (skin, intestine, kidney); amyloidosis and glomerulopathy
• Autoantibody activity of IgM: Chronic AIHA
  • (prominent rouleaux; 10% Coombs’ ⊕ = AIHA).
  • Peripheral neuropathy: may be due to IgM against myelin-associated glycoprotein.