Info

🌱 來自: NSCLC Treatment

introduction of NSCLC Treatment

• Localized disease: surgery if possible; RT (eg, stereotactic ablative radiotherapy [SABR]) vs. chemo/RT if not (see Figure 5-7)

• Metastatic disease: >20 new Rx since 2015. Some targeted Rx substantially improves survival & are better tolerated (see Stage IV Rx table); however, 5-y survival still poor.

• First-line immunotherapy (IO) ± chemo for most Pts w/o targetable mutations.

• Pemetrexed + pembrolizumab often continued as maintenance when used.

• Palliative care ↑ survival (NEJM 2010;363:733); palliative RT for local sx from tumor/mets.

參考 ➡️ Early palliative care improved quality of life in patients with newly diagnosed metastatic NSCLC

• Avoid combining IO & targeted Rx, ↑↑ tox (eg, rash/diarrhea, lung/liver injury [can be fatal])

• Solitary brain metastasis (oligomet): surgical resection + brain radiation may ↑ survival