Info

🌱 來自: Phase I drug-metabolizing enzymes

CYP2C8

Involved in metabolism of paclitaxel to inactive metabolite, 6α-hydroxy paclitaxel 6 Allele variants have been identified; CYP2C83 occurs most frequently in Caucasians, while CYP2C82 occurs most frequently in African Americans. Both variants result in reduced enzymatic activity & ↑ exposure to paclitaxel