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🌱 來自: multiple myeloma (MM)
treatment and prognosis of multiple myeloma (MM)🚧 施工中
treatment and prognosis of multiple myeloma (MM)
(NEJM 2016;375:754 & 1319; 2018;378:518 & 379:1811)
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Decisions dictated by risk stratification and transplant eligibility; generally incurable. Stratify via ISS criteria; R-ISS which includes chrom abnl & LDH (JCO 2015;61:2267).
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Relapsed refractory of treatment and prognosis of multiple myeloma (MM):
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Local radiation for solitary or extramedullary plasmacytoma
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Adjunctive Rx: bone: bisphosphonates (JCO 2007;25:2464), XRT for sx bony lesions
renal:
- avoid NSAIDs & IV contrast
- consider plasmapheresis for acute renal failure
- hyperviscosity syndrome: plasmapheresis
- infxns: consider IVIg for recurrent infections