polyps
Pathophysiology & epidemiology (NEJM 2016;374:1065)
- Accumulation of mutations in colonic epithelial cell DNA affecting oncogenes & tumor suppressor genes
- → tumor initiation (formation of adenoma; APC loss of fxn)
- → tumor progression (adenoma → carcinoma; K-ras gain of fxn, DCC, p53 loss of fxn)
- increased risk for colorectal cancer
- Protective factors for colorectal cancer
- Neoplastic polyps
- Non-neoplastic polyps
- CRC screening
- hamartomatous polyps