Info

🌱 來自：chronic myelogenous leukemia (CML)

definition of chronic myelogenous leukemia (CML)

(Blood 2009;114:937)

• Myelo-proliferative neoplasm  w/ clonal overproduction of : hematopoietic myeloid stem cells that can differentiate
• A dysregulated production & uncontrolled proliferation of mature/maturing granulocytes
• 15–20% of adult leukemias,
• approx 5,000 new cases/y in the United States,
• 1–2 cases per 100,000 adults,
• median age ∼64 (United States),
• younger median age in Asia/Africa

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• (Ph) = t(9;22)
• → BCR-ABLE1 fusion
• → ↑ Able kinase activity

如果其他的表現都一樣，但 Ph negative : myeloproliferative neoplasm

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BCR-ABLE1 required for diagnosis (make via karyotyping or FISH; PCR)