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🌱來自: tumor lysis syndrome

Clinical manifestations of tumor lysis syndrome

(NEJM 2011;364:1844) • Large tumor burden or a rapidly proliferating tumor → spontaneous or chemotherapy-induced release of intracellular electrolytes and nucleic acids • Most common w/ treatment of high-grade lymphomas (Burkitt’s) and leukemias (ALL, AML, CML in blast crisis). Very rare w/ solid tumors; rarely due to spont. necrosis. • Electrolyte abnormalities: ↑ K, ↑ uric acid, ↑ PO4 → ↓ Ca; renal failure (urate nephropathy)