Non-tuberculous mycobacterium-bronchiectasis

(NTM; eg, MAC, Mycobacterium kansaii)

• Chronic cough, ↓ wt; Lady Windermere syndrome: R middle lobe and lingula bronchiectasis in elderly ♀ who suppress expectoration

• Dx: CT scan (tree-in-bud, nodules, cavities, bronchiect.), sputum ×3 or BAL, AFB stain + Cx

• Treatment: susceptibility-based Rx pref over empiric Rx w/ [azithro or clarithro] + rifamycin & ethambutol for ≥12 mo (CID 2020;71:e1)