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🌱 來自: acute leukemia

epidemiology and risk factors of acute leukemia

Acute myelogenous (AML):

~20k cases/y in U.S.; median age 68 y

Acute lymphocytic (ALL):

~6k cases/y in U.S.; median age 15 y but 2nd peak in older adults

risk factors of acute leukemia

secondary to acquired hematopoietic dis.:

• MDS,
• MPN (esp. CML),
• aplastic anemia,
• PNH

Inherited:

• Down’s,
• Klinefelter’s,
• Fanconi’s anemia,
• Bloom syndrome
• ataxia telangiectasia,
• germline mut. in TP53 (Li-Fraumeni syndrome),
• DDX41,
• RUNX1, 
• CEBPa,
• GATA2