Info
🌱 來自: Huppert’s Notes
Sarcoma🚧 施工中
Sarcoma
Soft tissue sarcoma
• Epidemiology: Rare, heterogeneous tumor of mesenchymal origin. <1% of adult tumors. Most common soft tissue sarcoma = GI stromal tumor (GIST).
• Clinical features: Presents as gradually enlarging, painless mass. May have neuropathy or pain due to local compression. Common locations thigh/buttock/groin (46%) > torso (18%) > upper extremity or retroperitoneum (13% each).
• Diagnosis: Percutaneous core biopsy
• Staging: CT chest
• Treatment: Surgical excision if possible followed by radiation and chemotherapy (AIM = doxorubicin (Adriamycin), ifosfamide, mesna). Consider neoadjuvant therapy for large tumors to shrink tumor before surgery. For metastatic disease, give chemotherapy and consider resection of metastatic sites if limited (metastasectomy).
Osteosarcoma
• Epidemiology: Rare bone tumor; many are secondary to other conditions in adults (e.g., Paget disease of bone)
• Clinical features: Localized bone pain; systemic symptoms are rare
• Diagnosis: MRI of suspected primary site, biopsy (open vs. core, coordinate location of biopsy with orthopedic surgeon)
• Staging: CT chest
• Treatment: Neoadjuvant chemotherapy (doxorubicin + cisplatin), surgical resection, and possibly radiation therapy. Chemotherapy for metastatic disease +/– metastasectomy.