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🌱 來自: Colon Cancer

Molecular classification of Colon Cancer

Consensus molecular subtypes of colon CA:

• CMS1
  • MSI Immune,
  • hypermutated,
  • immune infiltrated,
  • BRAF V600E mut
• CMS2
  • canonical/epithelial,
  • MSS,
  • CIN,
  • Wnt/Myc activation,
  • EGFR dependent
• CMS3
  • metabolic,
  • CIN-MSI mixed,
  • metabolic dysregulation,
  • KRAS mut
• CMS4
  • mesenchymal,
  • MSS,
  • CIN,
  • activated TGFb,
  • & angiogenesis pathway,
  • immune tolerant,
  • worst prognosis