Clinical manifestations-adrenal insufficiency

(Lancet 2021;397:613)

• Primary or secondary: weakness and fatigability (95%), weight loss (70%), orthostatic hypotension (60%), nausea (50%), vomiting (50%), hyponatremia (75%)
• Primary only (extra s/s due to lack of aldosterone and ↑ ACTH): marked orthostatic hypotension (because volume depleted), salt craving, hyperpigmentation (seen in creases, mucous membranes, pressure areas, nipples), hyperkalemia
• Secondary only: ± other manifestations of hypopituitary syndromes