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🌱 來自：marginal zone lymphoma

Pathogenesis of marginal zone lymphoma

• Thought to arise from chronic Ag stimulation due to infectious pathogens or other causes of inflammation, including autoimmune diseases

• Variety of chromosomal translocations can result

  • in Ag-independent activation of
    • NF-ҡB pathway
      • (important signal for B cell survival)

• Whole genome sequencing of splenic MZL has

  • identified recurrent somatic Mts of
    • genes encoding chromatin-modifying enzymes & proteins
      • in the NOTCH, NF-κB, & MYD88 pathways
        • (JEM 2012;209:1537; NEJM 2012;367:826)

Suspected Antigen or Inflammatory Associations in MZL

CH-ABC

• Intestine: Campylobacter jejuni —C

• Gastric (most common): Helicobacter pylori —H

• Lung: Achromobacter xylosoxidans （塞羅=木糖） — Achromobacter （achromo=無色）

• Cutaneous: Borrelia species a.k.a. Lyme disease —B

• Orbital/ocular: Chlamydia psittaci —Chlamydia

• Salivary/lacrimal gland: Sjögren syn

• Thyroid: Hashimoto thyroiditis

• Joint/synovial tissue: Relapsing polychondritis

Splenic MZL: Spleen: HCV