Thalassemias

Mentzer index

• Hb 的 α 或 β 珠蛋白鏈的合成 ↓
• 溶血性貧血和無效造血的發生

(Lancet 2018;391:155)

• ↓ synthesis of α- or β-globin chains of Hb → ≠ subunits → destruction of RBCs and erythroid precursors; ∴ anemia from hemolysis and ineffective erythropoiesis

分類

• α-thalassemia
• β-thalassemia
• Special clinical manifestations of Thalassemias
• Dx of Thalassemias
• Treatment of Thalassemias

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