Acetaminophen hepatotoxicity
(Clin J Transl Hepatol 2016;4:131; BMJ 2016;353:i2579)
-
CYP2E1 induced by fasting, alcohol, certain anticonvulsants and anti-TB drugs, resulting in injury with even low doses (2–6 g) of acetaminophen
-
Liver dysfunction may not be apparent for 2–6 d; nausea, vomiting & abdominal pain 1st sx