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Management: Asymptomatic Stages III–IV (or intra-abdominal Stage II)

Observation is recommended for asx pts: serial clinical exams & periodic CT (PET is suspicion of transformation). Optimal timing of scans not determined, tailored to individual pt characteristics In observed pts, median time to initiation of Rx is ~3.5 y, & ~20% never require Rx No OS advantage has been demonstrated w/ early initiation of Rx