Info
🌱 來自: Huppert’s Notes
Targeted Therapies🚧 施工中
Targeted Therapies
• Nomenclature:
- Small molecule inhibitors end in “-inib”
- Monoclonal antibodies end in “-mab”
• Tyrosine kinase inhibitors: Small molecule inhibitors, given orally
- Imatinib (Gleevec), dasatinib: Bind to the inactive form of BCR-ABL and prevent activation. Used for treatment of CML.
- Osimertinib, erlotinib: EGFR inhibitors used in NSCLC
- Sorafenib, sunitinib: VEGF inhibitors used in HCC, RCC, thyroid
• Monoclonal antibodies: Given via infusion
- Anti-HER2: Trastuzumab (Herceptin), pertuzumab (Perjeta) used in breast cancer. Trastuzumab also used in esophageal/gastric cancer.
- Anti-CD20: Rituximab, targets B-cells, used in B-cell lymphomas
- Anti-VEGF: Bevacizumab (Avastin), inhibits angiogenesis, used in colon cancer, RCC