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🌱 來自: waldenstrom’s macroglobulinemia (WM)

definition of waldenstrom’s macroglobulinemia (WM)

(Blood 2009;114:2375; NEJM 2012;367:826)

• Waldenström 巨球蛋白血症 (WM)
• 罕見目前無法治癒的表達 IgM 的 B 淋巴細胞腫瘤，
• 其特徵是血清中出現單克隆 IgM (mIgM) 副蛋白以及惡性淋巴漿細胞浸潤造血骨髓。

• B-cell neoplasm (lympho-PLASMAcytic lymphoma) : that secretes monoclonal IgM
• 91% w/ MYD88 (NF-κB pathway) L265P mut., may distinguish from MM
• No evidence of bone lesions (IgM M component + lytic bone lesions = “IgM myeloma”)